Principles of Neural Stem Cell Lineage Progression

Simon Hippenmeyer
Professor – Life Sciences Research Area Chair
Institute of Science and Technology Austria (ISTA)

Résumé : The concerted production of the correct number and diversity of neurons and glia by neural stem cells is essential for intricate neural circuit assembly. In the developing cerebral cortex, radial glia progenitors (RGPs) are responsible for producing all neocortical neurons and certain glia lineages. Clonal analysis by exploiting the single cell resolution of the genetic MADM (Mosaic Analysis with Double Markers) technology revealed an inaugural quantitative framework of RGP behavior in the developing neocortex. However, the cellular and molecular mechanisms controlling RGP lineage progression through proliferation, neurogenesis and gliogenesis remain largely unknown. To this end we use quantitative MADM-based experimental paradigms at single RGP resolution to define the cell-autonomous functions of candidate genes and signaling pathways controlling RGP-mediated neuron and glia genesis. Ultimately, our results shall translate into a deeper understanding of brain function and why human brain development is so sensitive to the disruption of particular signaling pathways in pathological neurodevelopmental and psychiatric disorders.

Invité par Jean-Bernard Manent

Lundi 24 février 2025 à 11h – Salle de conférence de l’Inmed

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