– Monitoring the Monitors: the ETV1/Er81-dependent Molecular Control of Interneuron Function –

Dr Nathalie Dehorter
Group Leader at the Eccles Institute for Neuroscience
The John Curtin School of Medical Research, The Australian National University – Canberra

Abstract
Interneurons are the main controller of the excitatory/inhibitory balance, sensory tuning and plasticity. Yet, it is unclear how their activity is regulated at the molecular level to shape complex network functions and behaviour. During my talk, I will present a mechanism essential to the temporal processing capabilities of the cortical and striatal networks. I will show that the ETV1/Er81 transcription factor is required for normal circuit activity and time-locked responses to sensorimotor inputs in awake mice. I will demonstrate that ETV1/Er81 fine-tunes interneuron activity and that specific ablation of the transcription factor in cortical and striatal interneurons leads to prominent changes in their molecular, morphological, and electrophysiological features. Finally, I will discuss how this cell type-specific molecular control of interneuron activity drives mouse behaviour in health and disease.

Invited by Michel Picardo

Zoom Metting – Monday, December 6th at 10:00 am

https://zoom.us/j/98932883639?pwd=blQ5bzFwS0VmMTlLZWxZWEtqMklHQT09

ID de réunion : 989 3288 3639
Code secret : XdU04u