Network dynamics in the mouse piriform cortex during olfactory perception and memory

Lisa Roux
Team Leader Olfaction & Memory – IINS, Centre Broca Nouvelle-Aquitaine, Bordeaux

Résumé :
Sensory perception depends on interactions between external inputs transduced by peripheral sensory organs and internal network dynamics generated by central neuronal circuits. In sensory cortex, desynchronized network states associate with high signal-to-noise ratio stimulus-evoked responses and heightened perception. Cannabinoid-type-1-receptors (CB1Rs) – which influence network coordination in the hippocampus – are present in anterior piriform cortex (aPC), a sensory paleocortex supporting olfactory perception. Yet, how CB1Rs shape aPC network activity and affect odor perception is unknown. We addressed these questions using behavioral assays and pharmacological manipulations coupled with multi-electrode recordings or fiber photometry in the aPC of freely moving mice. I will first present our results showing that endocannabinoid signaling regulates network dynamics and thereby the tradeoff between detection and discrimination capacities. Then, I will share preliminary observations on the physiology and function of piriform population bursts which – similar to hippocampal ripples – could support olfactory memory consolidation during sleep.

Invitée par Françoise Muscatelli
Lundi 1er juillet à 11h – salle de conférence