Neurodevelopment-specific impairment in brain structure and function in mouse models of HCN/h channelopathies
Prof. Dr. Dirk Isbrandt
DZNE – Uniklinikum Köln
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The hyperpolarization-activated cyclic nucleotide-gated nonselective cation (HCN) channels mediate I(h) and are important determinants of the biophysical properties of neurons. Changes in expression patterns, subcellular localization, or biophysical characteristics of HCN channels have been associated with neurological dysfunctions ranging from motor learning deficits to neurological diseases such as epilepsy.
My team and I seek to model the aspects of human HCN/h channel dysfunction by generating transgenic and knockin mouse lines. We specifically aim at identifying age- or developmental stage-specific or neuron type-specific effects of HCN/h channel dysfunction. I will present our findings demonstrating surprisingly distinct roles of HCN/h channels during pre-and postnatal CNS development. The different age-dependent developmental phenotypes observed in our mouse lines may provide a model to investigate the range and variability of neurological dysfunctions associated, e.g., with HCN1 mutations in human patients.

Invité par Roustem Khazipov
Lundi 27 mai 2024, à 11h – Salle de conférence de l’Inmed


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