Royer B - Soares DC - Barlow PN - Bontrop RE - Roll P - Robaglia-Schlupp A - Blancher A - Levasseur A - Cau P - Pontarotti P - Szepetowski P


BMC genetics


The X-linked SRPX2 gene encodes a Sushi Repeat-containing Protein of unknown function and is mutated in two disorders of the Rolandic/Sylvian speech areas. Since it is linked to defects in the functioning and the development of brain areas for speech production, SRPX2 may thus have participated in the adaptive organization of such brain regions. To address this issue, we have examined the recent molecular evolution of the SRPX2 gene.

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