Séminaire externe présenté par Dr Thérèse Jay

Date : 3 juin 2013 à 11h

Lieu : Inmed – Salle de conférence

Improving the treatment of psychiatric disorders require better understanding of the underlying pathophysiological mechanisms in producing different phenotypic outcomes. Using complementary methodologies, animal models and clinical research, our goal within the last years has been to examine the prevalence of factors like stress, pre or perinatal insults and remodeling during puberty on the development of psychosis and depression. I will present data from animal models showing – a fundamental role of the prefrontal cortex in the maladaptive responses to stress, the mechanisms critically involved in the disruptive effects of stress with potential molecular targets and new strategies for drug development – a promising animal model for psychosis onset (validation of the MAM E17 model) – interactions between cannabis and brain development demonstrating that repeated exposure to cannabinoids during adolescence can significantly alter the level of prefrontal plasticity. The interchange between basic animal models and human pathophysiology should help to foster development of innovative preventive strategies or treatments and to identify biomarkers predicting the onset and the outcome of these disorders.
Thérèse M. Jay, Lab Physiopathologie des Maladies Psychiatriques
INSERM U894, Centre de Psychiatrie et Neurosciences
Université Paris Descartes
Paris, France