The dynamics of evidence accumulation and response execution during rule-guided decisions
Jaime de la Rocha
Group Leader at IDIBAPS, Barcelona
Résumé : Deciding requires integrating information from multiple sources over multiple time-scales. In perceptual decisions, for instance, ambiguous stimuli require fast accumulation of sensory evidence, a process largely studied but whose underlying mechanisms remain largely debated. Recent experiences on the other hand, can also impact the way we decide by reinforcing rewarded choices and strategies creating a dynamic prior framework that guides subsequent decisions. Where in the brain these decision variables are represented, updated and integrated to drive responses, it still unknown. In this talk I will present extensive data from rats performing a two-alternative decision-making task, which requires temporal integration within or/and across trials. I will show that rats can leverage on the latent statistical structure of the task and consistently develop a tendency to predict the upcoming stimulus from the previous responses and outcomes. Then I will show that the timing and the full orienting response trajectory can be explained by a novel model which, building on the standard accumulation to evidence models, incorporates proactive responses whose trajectories can be updated as the stimulus information reaches the decision bounds. Finally, using this behavioral model, pharmacological and optogenetic manipulations as well as electrophysiological recordings, I will characterize the role of several brain areas in this behavior, particularly of the dorsal striatum. Together, these results reveal that the accumulation of evidence across trials can exhibit complex dynamics and that the striatum plays a critical role in encoding these decision variables.
Invité par David Robbe et Lorenzo Fontolan
Lundi 3 février 2025 à 11h – Salle de conférence de l’Inmed
Publications :
Fast and tight control of motor vigor by accumulated decision evidence
M Molano-Mazón, A Garcia-Duran, J Pastor-Ciurana, Ll Hernández-Navarro, L Bektic, D Lombardo, J de la Rocha*, A Hyafil*
bioRxiv 2023.11.09.566389
Isolating perceptual biases caused by trial history during auditory categorization
Daniel Duque and Jaime de la Rocha
bioRxiv 2022.01.17.476581
Proactive and reactive accumulation-to-bound processes compete during perceptual decisions
Lluís Hernández-Navarro, Ainhoa Hermoso-Mendizabal, Daniel Duque, Jaime de la Rocha*, Alexandre Hyafil*
Nature Communications, 12(1), 1-15. 2021.
Ecologically pre-trained RNNs explain suboptimal animal decisions
Manuel Molano-Manzón, Yuxiu Shao, Daniel Duque, Guangyu Robert Yang, Srdjan Ostojic and Jaime de la Rocha
Current Biology 33(4), p622-638. 2023
Response outcomes gate the impact of expectations on perceptual decisions
Ainhoa Hermoso-Mendizabal*, Alexandre Hyafil*, Pavel E. Rueda-Orozco, Santiago Jaramillo, David Robbe, Jaime de la Rocha (*equal contribution)
Nature Communications 11, 1057, 2020