MicroRNAs: adaptation’s swiss knives
Eduardo Gascon Gonzalo
Chef d’équipe Sonic – Social Cognition and Connectomics – INT

Résumé
Epigenetic mechanisms have been long identified as essential regulators of gene expression. Among them, microRNAs, a class of short non-coding RNAs, have been intensively studied in the last decades. It is now well-established that they are key players in fine-tuning gene expression in numerous biological and pathological process. We are interested in: i) investigating how microRNAs participate in the crosstalk between genetic and environmental factors to shape brain trajectories along development; and ii) determining their role in vulnerability to psychiatric diseases, namely major depressive disorder. For that purpose, we are combining mouse and marmoset work and developing novel Cas9 approaches to inactivate specific microRNAs in precise brain networks.

Invité par Françoise Muscatelli
Lundi 26 janvier 2026 à 11h – salle de conférence de l’Inmed