CossartDec19Siteweb    CossartDec19Siteweb_2


Authors: L Modol, Y Bollmann, T Tressard, A Baude, A Che, ZR Duan, R Babij, N De Marco Garcia and R Cossart

Scientific Abstract: The developmental journey of cortical interneurons encounters several activity-dependent milestones. During the early postnatal period in developing mice, GABAergic neurons are transient preferential recipients of thalamic inputs and undergo activitydependent migration arrest, wiring, and programmed cell-death.  Despite their importance for the emergence of sensory experience and the role of activity in their integration into cortical networks, the collective dynamics of GABAergic neurons during that neonatal period remain unknown. Here, we study coordinated activity in GABAergic cells of the mouse barrel cortex using in vivo calcium imaging. We uncover a transient structure in GABAergic population dynamics that disappears in a sensory dependent process. Its building blocks are anatomically clustered GABAergic assemblies mostly composed by prospective parvalbumin-expressing cells. These progressively widen their territories until forming a uniform perisomatic GABAergic network. Such transient patterning of GABAergic activity is a functional scaffold that links the cortex to the external world prior to active exploration.

Published in Neuron, December 2019

Partager l'article