Auteurs
Eftekhari S - Shahrokhi A - Tsintsadze V - Nardou R - Brouchoud C - Conesa M - Burnashev N - Ferrari DC - Ben-Ari Y
Journal
Science (New York, N.Y.)
Abstract
Bambini-Junior et al. questioned whether our treatment in two rodent models of autism has a long-lasting effect into adulthood. In response, we show that bumetanide treatment around delivery attenuates autistic behavioral features in adult offspring. Therefore, the polarity of γ-aminobutyric acid (GABA) actions during delivery exerts long-lasting priming actions after birth.
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