Auteurs

Leventer RJ - Cardoso C - Ledbetter DH - Dobyns WB

Journal

Neurology

Abstract

Classical lissencephaly is a disorder of neuroblast migration with most patients having mutations of either the LIS1 or DCX genes. Most patients with lissencephaly secondary to LIS1 mutations have a severe malformation consisting of generalized agyria and pachygyria. However, increasing experience suggests that the phenotypic spectrum is wider than previously thought.

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