Auteurs
Tarhini S - Crespo-Quiles C - Buhler E - Pineau L - Pallesi-Pocachard E - Villain S - Saha S - Silvagnoli L - Stamminger T - Luche H - Cardoso C - Pais de Barros JP - Burnashev N - Szepetowski P - Bauer S
Journal
Journal of neuroinflammation
Abstract
Congenital cytomegalovirus (CMV) infections represent one leading cause of human neurodevelopmental disorders. Despite their high prevalence and severity, no satisfactory therapy is available and pathophysiology remains elusive. The pathogenic involvement of immune processes occurring in infected developing brains has been increasingly documented. Here, we have used our previously validated rat model of CMV infection of the fetal brain in utero to test whether the maternal administration of four different drugs with immunomodulatory properties would have an impact on the detrimental postnatal outcome of CMV infection.