Auteurs
Laumonnier F - Roger S - Guérin P - Molinari F - M'rad R - Cahard D - Belhadj A - Halayem M - Persico AM - Elia M - Romano V - Holbert S - Andres C - Chaabouni H - Colleaux L - Constant J - Le Guennec JY - Briault S
Journal
The American journal of psychiatry
Abstract
Autism is a complex, largely genetic psychiatric disorder. In the majority of cases, the cause of autism is not known, but there is strong evidence for a genetic etiology. To identify candidate genes, the physical mapping of balanced chromosomal aberrations is a powerful strategy, since several genes have been characterized in numerous disorders. In this study, the authors analyzed a balanced reciprocal translocation arising de novo in a subject with autism and mental retardation.