Neural mechanisms of predictive processing in the mouse visual cortex
Ede Rancz
Team leader Circuits corticaux

Abstract
My research examines how cellular and synaptic mechanisms shape circuit computations and behaviour across scales. Early work revealed region-specific tuning of inhibitory and modulatory synaptic processes, while doctoral studies in the cerebellum demonstrated that individual synapses and dendritic compartments exert precise control over neuronal gain and temporal coding. Postdoctoral research linked intrinsic physiology to projection-defined cortical connectivity, uncovering parallel processing streams within deep layers, and systems-level work showed that vestibular signals engage widespread cortical networks.
Since establishing my laboratory, I have focused on predictive processing in the mouse secondary visual cortex, targeting layer-5 extratelencephalically projecting neurons. We have shown that long-range inputs are compartmentalised along dendrites and that intrinsic morphology constrains nonlinear integration. Using a custom sensory–motor mismatch platform, we find that sensory-motor mismatches rapidly modulate activity in the visual cortex and influence gaze control.
Future work will determine how serotonin regulates predictive computations through receptor- and compartment-specific mechanisms. By combining in vitro physiology, in vivo recording of neural and neuromodulatory dynamics, and causal behavioural manipulations, this programme will link single-cell level modulation to circuit function and adaptive behaviour, establishing the secondary visual cortex as a mechanistically grounded model of predictive processing.

Jury
Valery MATARAZZO, President – Inmed U1249, Marseille
Francesca SARGOLINI, Rapportrice – CRPN U7077, Marseille
Bénédicte AMILHON, Rapportrice – Centre de recherche Azrieli du CHU Ste-Justine, Canada
Alberto BACCI, Rapporteur – ICM, Paris
Andrew MACASKILL, Invited members – UCL, Londres
Andréas FRICK, Invited members – Neurocentre Magendie, Bordeaux

Tuesday, 31 March 2026 at 2 pm – INMED conference room