Reelin in vulnerability and sex-dependent maturational trajectories of the prefrontal cortex
Abstract
Reelin is a secreted glycoprotein of the extracellular matrix serving multiple functions in the central nervous system. During embryonic development, reelin is essential to layer formation. In the maturing and adult central nervous system, reelin is instrumental to the postnatal developmental trajectories of the medial prefrontal cortex (PFC) at the structural, synaptic and behavioral levels. One distinctive feature of the PFC is its protracted maturation through early adulthood. This extended maturational period and especially adolescence represents a sensitive window for abnormal maturation of the PFC following exposure to environmental adversities. The PFC postnatal maturation is also under the influence of pubertal onset and sex differences. Using electrophysiological, imaging, and biochemical approaches, we showed that the reelin-controlled functional maturation of medial PFC networks is sex-dependent and vulnerable to environmental insult during adolescence such as drug exposure.

 

Jury
Rapporteur – Emmanuel VALJENT, Institut de Génomique Fonctionnelle – IGF, Montpellier
Rapporteur – Yves Jossin, Institute Of NeuroScience – IONS, Université de Louvain
Examinateur – Kenneth Mackie, Gill Center for Biomalecular Science, Indiana University Bloomington
Présidente du jury – Pascale DURBEC, Institut de Biologie du Développement de Marseille – IBDM
Directrice de thèse – Pascale CHAVIS, Institut de Neurobiologie de la Méditerranée – INMED

 

Thenzing SILVA HURTADO, team : Adolescence and developmental vulnerability to neuropsychiatric diseases – Pascale CHAVIS/Olivier MANZONIE

Visioconférence

Vendredi 10 décembre 2021 à 15h

 

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