– Release of stem cells from quiescence reveals multiple gliogenic domains in the adult brain –

University of Bassel, Swiss

Abstract:

Quiescent neural stem cells (NSCs) in the adult ventricular-subventricular zone (V-SVZ) have a regional identity and undergo activation to generate neurons. The domains for gliogenesis are less explored.

We show that Platelet-derived Growth Factor Receptor beta (PDGFRβ) is expressed by adult V-SVZ NSCs that generate olfactory bulb neurons and glia with slow kinetics. We define the molecular pathways of quiescent NSCs and changes that occur upon their activation.

Selective deletion of PDGFRβ in adult V-SVZ NSCs leads to their release from quiescence uncovering multiple novel domains in the septal wall for oligodendrocyte and astrocyte formation. Unexpectedly, we identify a novel intraventricular oligodendrocyte progenitor inside the brain ventricles.

Together, these findings reveal different NSC spatial domains for gliogenesis in the adult V-SVZ that are largely quiescent and may have key functions for brain plasticity.

Invited by : Aurélie Carabalona

Inmed meeting room, Monday November 24th, 11 am