Regulation of the cation chloride co-transporters by the lipid fingerprints
Coralie di Scala
Academy Research Fellow, Neuroscience Center
University of Helsinki

Abstract
These past years, lipids, the main compound of the brain tissue, have gained interest in Neuroscience. Our understanding of brain lipid composition and organization is daily growing, and we are now gaining insight in their functional roles for the brain. Lipids are now strongly suspected to play key role in brain development, neuronal communication or plasticity and their deregulations have been linked to the etiology of several brain pathologies.
More specifically, my work investigates whether membrane lipids may modulate the brain inhibiting system by regulating the properties of a cation chloride co-transporter. Our findings revealed that this transporter optimally works in presence of specific lipid pattern within the membrane defined as lipid fingerprints. It also explored the contribution of the lipid fingerprints in epilepsy.

Invited par Rosa Cossart
Friday, September 6th at 11am – Inmed conference room