The timescale dynamics of epilepsies: from seconds to decades 
Christophe BERNARD, Team learder PhysioNet – INS, Marseille

Abstract: 
Continuous long-term recordings (months to years) in patients with epilepsy show that seizures are regulated in a circadian manner. Besides, these recordings allowed to prove the presence of a much slower rhythm (days to weeks) of seizures. They strongly suggest the existence of specific molecular processes that influence the time of occurrence of seizures. Both circadian and multidien rhythms are biological phenomena, common to many animals species and plants. I will show that cortical structures undergo dynamic reconfiguration of their molecular architecture in a daily manner in health and disease. Accounting for daily and multidien molecular rhythms is essential to our understanding of brain function and dysfunction.

Invited by Laurent Aniksztejn

Monday, January 13th 2025, at 11h – Inmed room conference