Auteurs
Ragot A - Pietropaolo S - Vincent J - Delage P - Zhang H - Allinquant B - Leinekugel X - Fischer A - Cho YH
Journal
Brain and behavior
Abstract
The inhibition of the Histone Deacetylase 6 (HDAC6) increases tubulin acetylation, thus stimulating intracellular vesicle trafficking and brain-derived neurotrophic factor (BDNF) release, that is, cellular processes markedly reduced in Huntington's disease (HD).