Giua G - Lassalle O - Makrini-Maleville L - Valjent E - Chavis P - Manzoni OJJ
Frontiers in cellular neuroscience
Fragile X syndrome (FXS), resulting from a mutation in the gene, is the most common monogenic cause of autism and inherited intellectual disability. encodes the Fragile X Messenger Ribonucleoprotein (FMRP), and its absence leads to cognitive, emotional, and social deficits compatible with the nucleus accumbens (NAc) dysfunction. This structure is pivotal in social behavior control, consisting mainly of spiny projection neurons (SPNs), distinguished by dopamine D1 or D2 receptor expression, connectivity, and associated behavioral functions. This study aims to examine how FMRP absence differentially affects SPN cellular properties, which is crucial for categorizing FXS cellular endophenotypes.