Associative and procedural forms of learning require the detection and integration of sensory information and the generation, through trial-and-error, of adaptive motor sequences. Such processes rely on changes in neuronal activity in the primary sensory cortex and in motor regions such as the basal ganglia. The goal of the team is to understand the neuronal mechanisms at play during learning, with a focus on sensory processing, motor control, and the sensorimotor transformation. For this, we design and engineer new behavioral tasks and use in vivo electrophysiology (tetrodes, silicon probes, optrodes), manipulation of neuronal activity (close-loop optogenetic stimulation, brain lesions, pharmacological inactivation), ex vivo electrophysiology (patch-clamp, mapping with laser scanning photostimulation) and behavioral/neural statistical analysis to draw correlations and causal links between features of the animal behavior and the dynamics of neuronal population, single cells or identified circuits.
2 years postdoc position. Deadline application 28th of February 2018
We are looking for candidate for a two years postdoc position to model, using reinforcement learning algorithms, the behavior of rats challenged in a time estimation task.
See document below for details on the project and how to apply:
- aFunctional changes within the cortical networks of sensory perception
- bRole of the motor cortex and basal ganglia in motor learning and control
- cRole of striatal cell-types in motor control
- dSensorimotor coupling between barrel cortex and striatum as a mechanism for action monitoring and modulation
Functional changes within the cortical networks of sensory perception
P.I.: Ingrid Bureau
The aim here is to understand how neural representation in the primary somatosensory cortex changes while an animal learns to associate a whisker stimulus with a rewarding motor response. We work at identifying the neuronal circuits underlying the transformation of the whisker cortical map and at finding neural correlates to whisker-triggered behaviors. To this aim, we combine behavioral studies and electrophysiological recordings in and ex vivo.
We also work on models of developmental diseases such as Fragile X syndrome or epilepsy to investigate the consequences of cellular alterations on functions of sensory circuits and on sensory-guided behaviors.
Role of the motor cortex and basal ganglia in motor learning and control
P.I.: David Robbe. With Jordane Louis, Mostafa Safaie and Teresa Jurado-Parras.
When observing animals in their natural environment, one is often fascinated by their capacity to execute fine-tuned behaviors adapted to a variety of complex and challenging situations. Even if the importance of innate capacity should not be undermined, adaptive behaviors are often acquired and improved through extensive practice and prolonged trial-and-error interaction with the environment. The biological algorithms and the neural implementations underlying this type of learning are largely unknown. We tackle these questions with an interdisciplinary approach combining behavior, electrophysiological and brain lesion experiments, data analysis and modeling (reinforcement learning theory).
We have developed a new behavioral paradigm in which rats try to maximize reward collection while saving energy during a multi-trial time estimation task. Interestingly, during learning, all animals progressively converged toward a similar embodied strategy: they perform a stereotyped running sequence whose duration match the time to estimate. By combining behavioral testing (alteration of task rules and environments) and modeling we aimed at understanding this learning process at an algorithmic level. Using lesion and chronic extracellular electrophysiology (tetrode and silicon probes) we also examining how the basal ganglia and motor cortex contribute to the implementation of these embodied motor strategy.
Role of striatal cell-types in motor control
P.I.: David Robbe. With Anass Tinakoua and Pauline Perron.
The striatum is the main entry point of the basal ganglia (BG) and there is a general agreement that the dorsal region of striatum (DS) is implicated in motor control. A long-standing hypothesis is that the DS contributes to the selection of actions via the concurrent activation of striatal neurons forming the so-called direct and indirect basal ganglia pathways. While this hypothesis is appealing its validity is far from being confirmed experimentally.
To address this question we developed a new locomotion-based task in which head-restrained mice are trained to start, maintain and stop running according to external cues to obtain rewards they can collect by licking. We combined electrophysiological and close-looped optogenetic-based perturbation to understand the contribution of striatal neurons forming the direct and indirect pathways in the control of locomotion and licking.
Sensorimotor coupling between barrel cortex and striatum as a mechanism for action monitoring and modulation
The primary somatosensory cortex projects heavily onto striatum. In this project we study the properties and the encoding activity of corticostriatal projections during a whisker-guided motor task.
External cool links
- A post defining scientific attitude versus dogmatic:
- A french excellent scientific radio show on the life of Marie-Curie.
- A great free tool for data analysis. Help with transparency, collaboration and reproducibility :