Modulation of inhibition by behavioral-state in mouse visual cortex
Sensory perceptions are modulated by the context in which they are experienced. In primary sensory areas, neuronal responses to sensory inputs are also modulated by behavioral states, including level of arousal, attention and locomotion. In the primary visual cortex (V1), visual responses of pyramidal neurons increase during locomotion. This response gain was suggested to be mediated through inhibitory neurons, resulting in the disinhibition of pyramidal neurons. Using in vivo two-photon calcium imaging in layers 2/3 and 4 in mouse V1, our results reveal that locomotion modulates the activity of excitatory and inhibitory neurons differently in darkness and during visual stimulation. Context-dependent locomotion responses were found in vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons, with the highest proportion among SST neurons. These findings resolve apparent contradictions in the literature and suggest an alternative to the disinhibitory model for gain control of sensory responses by behavioral state.
Centre for Integrative Physiology
Hugh Robson Building
University of Edinburgh
Edinburgh, EH8 9XD (United Kingdom)
Invitée par Rosa Cossart
Salle de conférence INMED Lundi 10 avril 2017 à 11h